Hotel Principe liegt zentral im historischen Zentrum Venedigs, direkt am Canal Grande. Vom Hotel aus sind Ghetto Ebraico, das Casino, die Rialtobrücke und die Piazza San Marco bequem erreichbar. Der Bahnhof ist etwa fünf Gehminuten entfernt, der Flughafen Marco Polo in rund 30 Minuten per Motorboot oder Taxi.
Das Hotel bietet 130 Zimmer, darunter 129 Doppelzimmer, verteilt auf fünf Etagen. Die Unterkünfte verfügen über Annehmlichkeiten wie Klimaanlage, Heizung, Teppichböden sowie Badezimmer mit Dusche und Badewanne. Zustellbetten sind auf Anfrage erhältlich, und einige Zimmer sind rollstuhlgerecht gestaltet.
Gäste finden im Hotel Restaurants, ein Café, eine Bar und ein Casino. Die Verpflegung umfasst Übernachtung mit Frühstück oder Halbpension mit reichhaltigem Frühstücksbuffet und À-la-carte-Abendessen. Zusätzliche Services sind Babysitting, medizinische Betreuung, Zimmerservice und Wäscheservice. Kreditkarten wie American Express, Visa, MasterCard, Diners Club und JCB werden akzeptiert.
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